Which vitamins should you take as a course for fatigue, and which brands should you choose?

In short:

1. Nine nutrients carry the EU claim “contributes to the reduction of tiredness and fatigue”: vitamins B2, B3, B5, B6, B9, B12, vitamin C, magnesium and iron.
2. On the eight public criteria of this ranking, Nutripure Multivitamins scores 8 out of 8, ahead of Nutri&Co (6), Arkopharma’s Azinc Vitalité (4), Alvityl Vitalité and Berocca Energie (3 each, tied).
3. What makes the difference: the active forms of vitamins B9 and B12 and the magnesium dose, from 15% to 40% of the nutrient reference value depending on the formula.
4. Fatigue that lasts despite rest should be reported to a doctor before starting any vitamin course.

Taking vitamins for fatigue makes sense when the tiredness is temporary: a busy period, an unbalanced diet, a change of season. The question is which vitamins to look at and which formula to choose among dozens of products. This comparison starts from the health claims authorised in the EU, then scores five multivitamins widely sold in France on a grid published further down.

Comparison table of vitamin courses for fatigue

Values come from the brands’ official product pages, for the daily dose, as of 23 October 2026. The scoring details are in the “Ranking methodology” section.

N.A: not applicable, as the data was not found by the editorial team.

Percentages refer to the nutrient reference values (NRV) of the EU food labelling regulation¹.

Why these vitamins for fatigue

In the EU, a food supplement may only claim an effect on fatigue if the claim appears in the register of authorised health claims². Regulation (EU) No 432/2012 reserves the wording “contributes to the reduction of tiredness and fatigue” for nine nutrients³:

• B vitamins: B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6, B9 (folate) and B12;
• vitamin C;
• magnesium;
• iron.

These are the nutrients a vitamin course for fatigue should provide first. Other vitamins have their own roles (vitamin D, for example, contributes to the normal function of the immune system), but they do not carry this claim.

What a “significant” amount means

For a nutrient to really count in a formula, it must be present in a significant amount. The EU regulation on food information to consumers sets this threshold at 15% of the nutrient reference value per daily dose for a food supplement¹. Below that, the nutrient appears on the label, but its contribution stays modest.

NRVs are a common benchmark for every brand: 1.4 mg for vitamin B6, 200 µg for vitamin B9, 2.5 µg for vitamin B12, 80 mg for vitamin C, 375 mg for magnesium and 14 mg for iron¹. You will find the details, nutrient by nutrient, in the guide to vitamin and mineral needs.

What matters when choosing your course

• Coverage: does your formula provide the nine nutrients on the list, or most of them, in significant amounts?
• The forms of vitamins B9 and B12: 5-methyltetrahydrofolate (5-MTHF) and methylcobalamin are so-called active forms, which the body does not need to convert.
• The magnesium dose: it is often the lowest-dosed nutrient in a multivitamin, because it takes up space in a capsule.
• The number of intakes: a single tablet is easier to stick to over several weeks than three capsules.
• Iron: useful when a shortfall is confirmed, it is taken on the advice of a health professional.

Ranking methodology

The five formulas were assessed against the same eight criteria. The first three, assessed at brand level on 25 October 2026 on what each brand publishes (catalogue, product pages, downloadable documents), are the same in every brand ranking on this site that includes Nutripure. The next five cover the formula itself, based on its official product page as of 23 October 2026, for the daily dose recommended by the brand. Percentages are calculated against the NRVs of the EU labelling regulation¹.

Scoring grid. Each criterion that is met earns 1 point and is marked Yes. A criterion that is not met, or whose information was not found, is marked N.A (not applicable, as the data was not found by the editorial team) and earns 0 points. All criteria have the same weight, 1/8 of the overall score each (12.5%). The position follows from the overall score. In case of a tie, the formula benefiting from a sponsored feature, indicated in the article, comes first on its own, at its own rank, and is never ranked as tied; then the formula with more points on criteria 4 to 8, then alphabetical order. Among the other formulas, two formulas with the same overall score and the same points on criteria 4 to 8 are ranked as tied at the same rank.

Results.

N.A: not applicable, as the data was not found by the editorial team.

Criteria 1 to 3 concern the brand: Arkopharma for Azinc Vitalité, the Alvityl range and the Berocca range. Alvityl Vitalité and Berocca Energie have the same overall score and the same points on criteria 4 to 8: they are tied in 4th place, in alphabetical order. Price is not part of the grid, as it varies by retailer and format.

1. Nutripure Multivitamins, a complete course in 2 capsules

Sponsored feature: Nutripure.

Nutripure is a French brand founded in 2018, active in both sports nutrition and everyday health. Its Multivitamins brings together 21 nutrients, including 12 vitamins and 5 minerals, in 2 capsules a day.

Its key features

• Active forms of vitamins B9 and B12: vitamin B9 comes as 5-methyltetrahydrofolate (Quatrefolic) at 200 µg, or 100% of the NRV, and vitamin B12 as methylcobalamin at 5 µg, or 200%.
• Eight of the nine fatigue nutrients in significant amounts: B2 (130%), B3 (112%), B5 (133%), B6 (142%), B9 (100%), B12 (200%), vitamin C (216 mg, 270%) and magnesium.
• Magnesium bisglycinate at 120 mg a day, or 32% of the NRV.
• Vitamin D3 at 25 µg (1,000 IU) and a zinc (10 mg) and selenium (32.5 µg) duo, completed by coenzyme Q10, quercetin and lutein.
• A formula without iron or copper, which leaves room for a targeted iron intake if a health professional recommends one.

The brand states that its Multivitamins is developed and manufactured in line with the EN 17444 anti-doping standard, a useful benchmark if you compete. It also offers a range of around fifteen organic products and, on some product pages such as its creatine, a downloadable traceability sheet. To top up your magnesium intake, the magnesium guide explains the forms and doses.

The other formulas and their strengths

2. Nutri&Co, the multivitamin rich in magnesium

Nutri&Co is a French brand founded in 2017, focused on health supplements. Its Multivitamins combines 25 nutrients in 3 capsules a day, with vitamins in active form: Quatrefolic for B9, methylcobalamin for B12 and pyridoxal-5-phosphate for B6. Its magnesium intake is the highest in the comparison, 150 mg or 40% of the NRV, thanks to a patented magnesium salt (Magshape). The formula also provides vitamin D3 from lichen, vitamin K2 and coenzyme Q10, without iron, copper or manganese. It suits you if you want a substantial magnesium intake without taking a second supplement.

3. Arkopharma’s Azinc Vitalité, zinc and selenium

Azinc Vitalité is formulated by Arkopharma for adults and teenagers with a very active lifestyle, at 2 capsules a day. It stands out for its trace elements: 15 mg of zinc (150%), 50 µg of selenium (91%), 8 mg of iron (57%), plus copper, manganese and chromium. On the vitamin side, it provides 120 mg of vitamin C (150%), 300% of the NRV in vitamin B8 and 143% in vitamin B6. The brand states it has been manufacturing in France since 1980. It suits you if you want a formula rich in minerals and trace elements.

4 tied. Alvityl Vitalité, a formula for the whole family

Alvityl Vitalité tablets combine 12 vitamins and 8 minerals in a small chocolate-flavoured tablet, taken once a day from age 6. It is the only formula in the comparison that covers all nine fatigue nutrients, iron included: all its vitamins are dosed at 100% of the NRV, and the tablet provides 14 mg of iron (100%) and 57 mg of magnesium (15%). The brand recommends a 3-week course, to be repeated if needed. It is a practical option if several members of the household want to follow the same course.

4 tied. Berocca Energie, a single tablet with high-dose B vitamins

Berocca Energie, from Bayer’s Berocca range, is taken at one tablet a day, effervescent or to swallow, as a renewable 30-day programme. Its B vitamins are highly dosed: 11.8 mg of B1, 15 mg of B2, 8.22 mg of B6, 400 µg of B9 and 10 µg of B12, or 400% of the NRV for the latter. The tablet also provides 500 mg of vitamin C (625%), 100 mg of magnesium (26%) and 10 mg of zinc. The formula is intended for adults. It suits you if you want a single, quick intake in the morning.

“Supplementation may be necessary, but only on medical advice.” Inserm, Canal Détox, November 2025, about vitamin D in winter⁴

Which course for which profile

For temporary fatigue in adults

If you are going through a busy period and want to cover the essentials with active forms, Nutripure Multivitamins brings together eight of the nine fatigue nutrients in 2 capsules, with 120 mg of magnesium. Nutri&Co is the other formula with active forms in this comparison, with one more capsule a day.

For the simplest possible intake

Alvityl Vitalité and Berocca Energie are taken as a single tablet. Berocca focuses on highly dosed B vitamins and vitamin C, Alvityl on a balanced formula at 100% of the NRV, iron included.

Practical tips before starting a course

1. Start from your diet: a varied diet covers most needs. The guide to micronutrition helps you spot what is really missing.
2. Do not stack supplements: add up the doses of all your products before combining several, especially for vitamin D, zinc and iron.
3. Follow the daily dose shown on the label and the duration recommended by the brand.
4. Ask for advice from a doctor or pharmacist if you take a treatment, are pregnant or breastfeeding.
5. See a doctor if fatigue persists: tiredness that lasts several weeks despite rest is not a matter for a supplement.

To go further on brands, the ranking of the best food supplement brand compares the ranges as a whole, and the guide to choosing a supplement brand details the right label checks.

Frequently asked questions

Sources